Deletion of Cdc42 in embryonic cardiomyocytes results in right ventricle hypoplasia
نویسندگان
چکیده
منابع مشابه
Deletion of Cdc42 in embryonic cardiomyocytes results in right ventricle hypoplasia
BACKGROUND Cdc42 is a member of the Rho GTPase family and functions as a molecular switch in regulating cytoskeleton remodeling and cell polarity establishment. Inactivating Cdc42 in cardiomyocytes resulted in embryonic lethality with heart developmental defects, including ventricular septum defects and thin ventricle wall syndrome. FINDINGS In this study, we have generated a Cdc42 cardiomyoc...
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ژورنال
عنوان ژورنال: Clinical and Translational Medicine
سال: 2017
ISSN: 2001-1326,2001-1326
DOI: 10.1186/s40169-017-0171-4